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Bio-Oligo 100 can synthesize 50μmol-9mmol of DNA/RNA. This oligo synthesizer machine using modular design and intelligent software combined with synthesis columns of different specifications can synthesize a certain amount of DNA/RNA, and this automated DNA synthesizer machine is used in clinical research, nucleic acid drug development and the synthesis of molecular diagnostic probes.
Stacked piping design, small dead volume, piping resistant to conventional organic solvents (acetonitrile, toluene), a certain concentration of dichloroacetic acid (3% ~ 10%) and other reagents;
PEEK material dual pump head with high flow accuracy and flow accuracy controlled at ± 1%; Flow repeatability: RSD ≤ 0.5%, pump head self-cleaning function;
Modular design that facilitates equipment maintenance, enables multi-user login and management, ensure information security and tracking;
Process parameters setting module customization, process method self-editing, good human-computer interaction experience;
Low reagent losses, high degree of automation, monitoring of synthesis pressure throughout, conductivity values, UV detection etc.
Cycle time: 4.5 ~25min (standard DNA), synthesis efficiency: > 99% for DNA, > 98% for RNA, can synthesize DNA / RNA of different sequence length;
Base monomer bottle quantities can be expanded to a maximum of 18, meeting the needs for the synthesis of modified monomers from a subset of customers;
Software design is compliant with the requirements of relevant laws and regulations such as 21 CFR Part 11.
| Synthesis scale | 50μmol-9mmol |
| Solvent compatibility | Deprotection reagents, BTT, Thio reagents, etc. |
| Pump | Piston pump, PEEK material, pump head self-cleaning function, double pump head design, 0~100ml/min |
| Column reactor | 1 pcs |
| Amidite bottle | Standard 8, expandable to 18 |
| Monomer inlet | 1 |
| Waste liquid outlet | 8 |
| Operating pressure | 15bar (218psi) |
| Inert gas pressure | 0.3~0.35 bar |
| UV detector | Wavelength range 190~ 400nm, accuracy ±1nm (double channel UV detector is optional) |
| Conductivity detector | 0～999mS/cm |
| Pipe material | PTFE tube, PEEK tube |
| Single cycle time | <30min |
| Synthesis efficiency | >99% for DNA >98% for RNA |
| Power supply | 220V±5% AC |
| Wattage | 900W |
| Weight | 55kg |
| Dimensions | 450*570*570mm |
| Operating temperature | 10~40℃ |
| Humidity | 0.3 |
