Jiangsu Hanbon Science&Technology Co., Ltd.
Jiangsu Hanbon Science&Technology Co., Ltd.

Biopharm Purification Equipment

Biopharm purification equipment independently developed by Hanbon includes Chromatography columns, Chromatography system, In-line buffer dilution system, Filtration system, Single-use system, etc. The device software meets the requirements of GLP/GMP regulations and FDA 21CFR part 11 requirements and has a complete IQ/OQ/PQ verification file system that can provide document support for user GMP/FDA certification.

Types of Biopharm Purification Equipment

Chromatography Column
Chromatography Column
The Hanbon chromatographic column has a compact structure design, and is easy to operate and maintain.
Chromatography System
Chromatography System
Hanbon chromatography system has reliable performance and flexible configuration, and can provide Bio-Lab® laboratory chromatography system, Bio-Pro® pilot&process chromatography system, etc.
Buffer Dilution/ Conditioning System
Buffer Dilution/ Conditioning System
It solves the need for precision and repeatability of complex buffer solutions, reduces the number of storage tanks, saves manpower and material resources for dispensing, and reduces production costs.
Filtration System
Filtration System
Hanbon filtration system is suitable for biopharmaceutical customers with different scales and process routes, including Bio-TFF tangential flow filtration System, Depth filtration system, Membrane cassette holders, etc.
Single-use System
Single-use System
We provide Single-use chromatography system and Single-use tangential flow filtration system, and all contact liquid components can be directly replaced, which is fast and convenient.
Basic Characteristics Of Chromatography Resins
Basic Characteristics Of Chromatography Resins

Basic Characteristics Of Chromatography Resins

  • Resin matrix: the finer and more uniform the particle size, the higher the resolution, but also the higher the backpressure (with the exception of the Source matrix);

  • Physical stability: new generation resins are more robust and can withstand high flow rates while maintaining a stable column bed volume and structure, eliminating the need for frequent column loading operations and improving reproducibility;

  • hemical stability: the new generation of resins can withstand extreme pH, high salinity, pro-solvents and organic solvents, facilitating the development of separation conditions and in-situ cleaning (CIP), greatly extending resin life and improving reproducibility.


Different packing materials can be used for different sample separations, requiring different columns and systems to be used with them.

Application Of Chromatography And Filtration Techniques In Vaccine Purification


Antibody drugs (mono-, di-, poly-, and ADCs) are novel therapeutics with high efficiency, low toxicity, and low side effects, and are widely used in cancer, autoimmune diseases, infectious diseases, and other fields. Antibody-drug purification protocols need to be optimized and adjusted according to specific antibody types and requirements, and downstream links usually include the following steps:


  • Cell harvesting and fragmentation

  • Affinity chromatography

  • Ion exchange chromatography

  • Size exclusion chromatography

  • Regeneration and concentration


Hanbon's chromatography systems, filtration systems, in-line dosing systems, and other products are inextricably linked to the separation and purification of antibody drugs and are essential tools for the preparation of high-quality antibody drugs, both in the process development and production stages.

Application Of Chromatography And Filtration Techniques In Antibody Purification

Vaccines are an effective means of preventing infectious diseases. In the process of vaccine preparation, viruses or bacteria need to be produced first by cell culture, etc., and then inactivated and lysed to obtain the vaccine stock solution. Next, the vaccine stock solution needs to be isolated and purified to obtain a high-purity vaccine product. In this process, Hanbon's chromatography system and ultrafiltration system can be used to separate and purify the target proteins in the vaccine stock solution to obtain a high-purity vaccine product. Specifically, affinity chromatography, ion exchange chromatography, and gel chromatography can be used to remove impurities from the vaccine raw material solution to obtain high purity vaccine products.

Application Of Chromatography And Filtration Techniques In Antibody Purification
GET IN TOUCH WITH HANBON
Whether you have a question about Hanbon Sci&Tech Co., Ltd.'s biopharmaceutical equipment or anything else, we're here to help and ready to answer your questions.
E-mail
globalbusiness@hanbon.com.cn
Call Us
+86-51783706900
Address
No.1-9 Jixian Road, Economic Development Zone, Huaian City, Jiangsu Province, China.
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